基本信息
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Career Trajectory
Bio
Matthew’s research is in field of gene therapy for degenerative disorders of the nervous system and muscle. The main focus is the investigation of novel therapeutic approaches utilising short nucleic acids to target messenger RNA. Targeting RNA has the potential to allow modification of the target transcript, reprogramming of endogenous genetic defects or the targeting of specific disease alleles, all the while maintaining endogenous regulation of the target gene. Current work is investigating the potential of single-stranded antisense oligonucleotides for the modification of mRNA splicing, for example in Duchenne muscular dystrophy. In addition, the potential of double-stranded RNA for gene silencing, known as RNA interference (RNAi), is being investigated for the silencing of target genes and mutant alleles both in muscle and in the nervous system. In particular, RNAi has great potential as a future therapeutic agent for currently untreatable neurodegenerative disorders such as Parkinson’s disease.
Research Interests
Papers共 417 篇Author StatisticsCo-AuthorSimilar Experts
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Emily Cybulla, Sierra Wallace,Alice Meroni,Jessica Jackson,Sumedha Agashe, Mithila Tennakoon, Mangsi Limbu,Annabel Quinet,Elena Lomonosova,Hollie Noia,Stephanie Tirman,Matthew Wood,
Nucleic acids research (2024)
Susan Isabel Honeyman, William J. Owen, Juan Mier,Katya Marks, Sohani N. Dassanyake,Matthew J. Wood,Rory Fairhead, Pablo Martinez-Soler, Hussain Jasem, Ananya Yarlagadda,Joy R. Roach,Alexandros Boukas,
JOURNAL OF MEDICINAL CHEMISTRYno. 13 (2023): 9223-9224
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Jessica Stoodley, Francisco Vallejo-Bedia, David Seone-Miraz, Manuel Debasa-Mouce,Matthew J A Wood,Miguel A Varela
EMBO molecular medicineno. 11 (2023): n/a-n/a
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Author Statistics
#Papers: 428
#Citation: 41348
H-Index: 85
G-Index: 200
Sociability: 8
Diversity: 0
Activity: 4
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