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Our research focuses on how cells sense their status and activate programmed cell death. We study molecules that switch from normal physiological functions to cell suicide functions relevant to neurodegeneration, host-pathogen interactions, and tumorigenesis. While a great deal is known about how apoptosis factors kill mammalian cells, little is known about their alternative physiological functions in healthy cells, or how these alternative functions impact subsequent cell death. Conversely, pro-death functions of yeast proteins are essentially unknown despite their many well-studied physiological functions. Ongoing projects apply a range of technologies and diverse model systems to discover and characterize these novel functions. Many life-death molecular switches affect membranes of subcellular organelles such as mitochondria, endoplasmic reticulum and autophagosomes/lysosomes. Our yeast discovery tools have uncovered cancer-like genome evolution as well as neurodegenerative disease mechanisms now being pursued in mouse models. Our studies in flies have advanced our studies of cell death in the mammalian brain. Also ongoing is the pursuit of evolutionarily conserved as well as unique cell death mechanisms potentially useful for controlling fungal pathogens.
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Zhenyi An,Andrea Ballabio, Lynda Bennett,Patricia Boya,Francesco Cecconi,Wei-Chung Chiang, Patrice Codogno,Maria Isabel Colombo,Ana Maria Cuervo,Jayanta Debnath,Vojo Deretic,Ivan Dikic,
user-5d7f3c40530c708f991f6404(2016)
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Journal of Visualized Experiments (2016)
Scientific Reportsno. 1 (2015): 1-7
X Teng,W-C Cheng,B Qi, T-X Yu, K Ramachandran, M D Boersma, T Hattier,P V Lehmann,F J Pineda,J M Hardwick
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