基本信息
浏览量:265
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Dr. Luke is one of the foremost international investigators in the realm of immuno-oncology, having led clinical trials of immunotherapies including but not limited to anti-PD1/L1, CTLA4, many secondary checkpoints, bispecific approaches (checkpoint, CD3 and cytokine), metabolism modifiers (IDO, A2Ar/CD73/CD39 and arginase), innate agonists of STING, TLRs and oncolytic virus as well as solid tumor cellular therapies (TCRs and CART). In melanoma, Dr. Luke has designed and led two practice changing trials determining the role of anti-PD1 + CTLA4 after initial anti-PD1 failure (compendium listed in the NCCN) and altering the landscape of melanoma oncology practice across dermatology, surgery and medical oncology via establishment of modern adjuvant therapy with anti-PD1 for node negative stage IIB/C disease (leading to FDA/EMA approval). Dr. Luke has been a major contributor toward the investigation of radiation and the microbiome in relation to cancer immunotherapy. Dr. Luke’s major translational research focus leverages large scale informatics to advance cancer immunotherapy. Dr. Luke has on-going NIH funding for his translational research laboratory which focuses on tumor-intrinsic mechanisms of immune exclusion and designing next generation immunotherapy approaches to overcome them.
研究兴趣
论文共 418 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 3 (2024)
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 4 (2024)
Current Oncology Reportsno. 7 (2024): 1-14
Journal for ImmunoTherapy of Cancerno. 4 (2024)
Journal of clinical oncology : official journal of the American Society of Clinical Oncologyno. 9 (2024): 1011-1020
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 1 (2024): 9-11
Jason J. Luke,Georgina V. Long, Caroline Robert,Matteo S. Carlino,Toni K. Choueiri,Naomi B. Haas, Mary O’Brien,Luis Paz-Ares,Solange Peters,Thomas Powles,Melanie A. Leiby,Jianxin Lin,
European Journal of Cancer (2024): 114146-114146
David H Aggen,Meredith McKean,Jean H. Hoffman-Censits,Nehal J. Lakhani,Omar Alhalabi,Elizabeth A. Guancial,Babar Bashir, I. Alex Bowman,Alan Tan,Trupti Lingaraj, Katherine Kim, Marissa Timothy,
Journal of Clinical Oncologyno. 16_suppl (2024): 2599-2599
Joseph J Sacco,Richard D Carvajal,Marcus O Butler, Alexander N Shoushtari, Jessica C Hassel,Alexandra Ikeguchi,Leonel Hernandez-Aya,Paul Nathan,Omid Hamid,Josep M Piulats,Matthew Rioth, Douglas B Johnson,
Journal for immunotherapy of cancerno. 6 (2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn