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个人简介
Lloyd John Old was one of the founders and standard-bearers of the field of cancer immunology.When Old began his career in 1958, tumor immunology was in its infancy. Today, cancer immunotherapies are emerging as a significant advance in cancer therapy.
Old’s contributions to research established many of the principles and priorities of modern tumor immunology. In earlier work, he and his colleagues introduced Bacillus Calmette-Guérin (BCG) to tumor immunotherapy; discovered the first link between the major histocompatibility complex (MHC) and disease (leukemia); found the unexpected association between Epstein-Barr virus (EBV) and nasopharyngeal carcinoma; discovered Tumor necrosis factors (TNF); defined the concept of cell-surface differentiation antigens with the discovery of TL, Lyt (CD8), and a range of other mouse antigenic systems; discovered p53, independently with two other groups; and identified the tumor immunogenicity of heat shock proteins. Old is the author or co-author of more than 800 research publications. He was also a teacher helping young scientist as they began their career.
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Aa Jungbluth,S Ely,M Diliberto, R Niesvizky, B Williamson, D Frosina,Yt Chen, N Bhardwaj,S Chen-Kiang,Lj Old,Hj Cho
Bloodno. 1 (2005): 167-174
AA Jungbluth,Y-T Chen, E Stockert,KJ Busam, D Kolb, K Iversen, K Coplan, B Williamson, N Altorki,LJ Old
International Journal of Cancerno. 6 (2002): 878-878
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