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What are the regulatory mechanisms that control homeostatic turnover, and how do their perturbation contribute to disease progression? Lungs are slow turnover organs that are highly quiescent at steady-state. However, the lung has a tremendous ability to repair epithelial damage following injury and contains multiple, highly plastic, stem cell populations. We are interested in understanding how stem cells respond to different signals from their local environment and orchestrate the changes in chromatin, transcription, translation, and cellular dynamics in homeostasis and injury repair. Questions that we are trying to address are: 1) what mechanisms regulate the transition of cells from quiescent to dividing and back again? 2) How do distinct cell types sense different injuries? 3) Which cell populations have the flexibility to de-differentiate and when are these complementary repair mechanisms used? Elucidating the normal process of lung dynamics will provide us a foundation to understand lung diseases and cancer.
We apply ex vivo 3D organoid cultures of human and mouse lungs with genetic tools, in vivo transgenic mouse models with lineage tracing techniques, quantitative mathematic modelling of clonal dynamics, and bioinformatics at the single cell level.
Our keywords include: quiescence, lineage specification, plasticity, reprogramming, heterogeneity, cell-cell competition, niche.
We apply ex vivo 3D organoid cultures of human and mouse lungs with genetic tools, in vivo transgenic mouse models with lineage tracing techniques, quantitative mathematic modelling of clonal dynamics, and bioinformatics at the single cell level.
Our keywords include: quiescence, lineage specification, plasticity, reprogramming, heterogeneity, cell-cell competition, niche.
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biorxiv(2023)
Jakub Chudziak,Joo-Hyeon Lee
The Journal of cell biologyno. 12 (2023)
bioRxiv : the preprint server for biology (2023)
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Nick Shrine,Abril G. Izquierdo,Jing Chen,Richard Packer, Robert J. Hall,Anna L. Guyatt,Chiara Batini,Rebecca J. Thompson, Chandan Pavuluri,Vidhi Malik,Brian D. Hobbs,Matthew Moll,
NATURE GENETICSno. 10 (2023): 1778-1779
Szu-Hsien Sam Wu,Somi Kim,Heetak Lee,Ji-Hyun Lee,Gabriele Colozza,So-Yeon Park,Réka Bakonyi,Isaree Teriyapirom, Natalia Hallay, Sandra Pilat-Carrota, Hans-Christian Theussl,Jihoon Kim,
crossref(2023)
Nature Geneticsno. 3 (2023): 410-422
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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