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Bio
Clinical Interests
Broadly speaking, our laboratory studies pulmonary host defense and molecular pathogenesis of acute lung injury. Our research focuses upon the innate arm of immunity, specifically examining effector function of myeloid cells such as macrophages and neutrophils and how they recognize and respond to exogenous pathogen associated molecular patterns or endogenous alarmins. We are interested in probing host-pathogen interactions to examine mechanisms of host protection following pathogen-triggered injury from products of extracellular gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae. We are also interested in the factors that shape repair and resolution following injury, specifically factors derived from hematopoietic cells such as platelets and red blood cells that can influence the course of inflammation. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine innate host defenses of the lung.
Broadly speaking, our laboratory studies pulmonary host defense and molecular pathogenesis of acute lung injury. Our research focuses upon the innate arm of immunity, specifically examining effector function of myeloid cells such as macrophages and neutrophils and how they recognize and respond to exogenous pathogen associated molecular patterns or endogenous alarmins. We are interested in probing host-pathogen interactions to examine mechanisms of host protection following pathogen-triggered injury from products of extracellular gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae. We are also interested in the factors that shape repair and resolution following injury, specifically factors derived from hematopoietic cells such as platelets and red blood cells that can influence the course of inflammation. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine innate host defenses of the lung.
Research Interests
Papers共 99 篇Author StatisticsCo-AuthorSimilar Experts
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W. Bain, B. Fuller,H. Bahudhanapati,M. Jiang,X. An,Z. Xiong,R. Van der Geest,M. Tabary,T. L. Suber, Y. Zhang,K. Chen,J. Lee,
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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N. J. Tolman,W. Bain, C. McElheny,R. Van Der Geest,S. Gonzalez-Ferrer,X. An, R. Hosuru,Z. Xiong,T. L. Suber,V. Ferreira,D. Van Tyne,Y. Doi,
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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C. Caglayan,B. Zuchelkowski, N. S. Mehdi,S. Qin, Y. Zhang,P. Ray,A. Ray,J. Lee,A. Morris,B. J. Mcverry,G. Kitsios,W. Bain
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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JOURNAL OF GENERAL INTERNAL MEDICINE (2023): S86-S86
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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S. Das,T. W. Kaminski,D. Rajasundaram, S. Hu, B. Schlege, A. Patel,S. L. Kale, K. Chen,P. Sundd,J. Lee,A. Ray,P. Ray
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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Author Statistics
#Papers: 98
#Citation: 471
H-Index: 10
G-Index: 21
Sociability: 6
Diversity: 2
Activity: 11
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