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Bio
Dr. Witztum's lab is interested in the mechanisms by which oxidation of lipoproteins causes atherosclerosis, and in particular how immune mechanisms contribute to this process.For more than 40 years, Dr. Witztum has made major contributions to the field of atherosclerosis. Alongside Dr. Daniel Steinberg, he first described the role of OxLDL in atherogenesis, providing fundamental information on its properties and evidence that it existed in experimental models and humans. He first showed that OxLDL was immunogenic, leading to both adaptive and innate immune responses to what he termed “oxidation-specific epitopes,” which fundamentally contributed to the concept that atherosclerosis was a chronic inflammatory disease. More recently, he has focused on defining the role of oxidized phospholipids in atherogenesis and inflammation in general.
Research Interests
Papers共 885 篇Author StatisticsCo-AuthorSimilar Experts
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Erik S.G. Stroes, Vickie Alexander, Ewa Prokopczuk,Robert Hegele,Marcello Arca,Christie M. Ballantyne,Handrean Soran,Thomas Prohaska,Shuting Xia,Henry Ginsberg,Joseph L. Witztum,Sotirios Tsimikas
Journal of the American College of Cardiologyno. 13 (2024): 1670
NEW ENGLAND JOURNAL OF MEDICINEno. 5 (2024): 476-477
Nature Reviews Cardiologyno. 3 (2024): 170-191
Journal of lipid researchno. 6 (2023): 100391-100391
Journal of clinical lipidologyno. 3 (2023): 406-411
Journal of Clinical Lipidology (2023)
Vickie Alexander, Ewa Prokopczuk,Erik S.G. Stroes, Christie M. Ballantyne,Henry Ginsberg,Shuting Xia,Joseph L. Witztum,Sotirios Tsimikas
Journal of the American College of Cardiologyno. 8 (2023): 1764-1764
Journal of thrombosis and thrombolysisno. 2 (2023): 226-232
bioRxiv : the preprint server for biology (2023)
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