基本信息
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Career Trajectory
Bio
My research vision is to apply basic biochemistry to solve medical and biological problems, and in the long run to develop new treatments of human diseases. We have designed a fully synthetic lung surfactant preparation for treatment of respiratory distress syndrome in premature infants and together with a pharmaceutical company taken it to phase II clinical development. We have also pioneered studies of a molecular chaperone, and recently shown that it has potent activity in Alzheimer disease mouse models, findings that we hope to take to human studies in the coming years. Finally, we have discovered how spider silk proteins assemble into fibers, and from this we have produced recombinant biological drugs as well as spun artificial silk. Much of this research has been performed in close, long-standing and fruitful collaborations with groups at KI as well as other universities and companies.
Research Interests
Papers共 630 篇Author StatisticsCo-AuthorSimilar Experts
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Gefei Chen,Yu Wang, Zihan Zheng,Wangshu Jiang,Axel Leppert,Xueying Zhong, Anna Belorusova, Gregg Siegal,Caroline Jegerschöld,Philip J B Koeck,Axel Abelein,Hans Hebert,
Protein science : a publication of the Protein Societyno. 7 (2024): e5063-e5063
Xingmei Qi,Han Wang, Kezhen Wang,Yu Wang,Axel Leppert,Igor Iashchishyn,Xueying Zhong,Yizhong Zhou, Ruifang Liu,Anna Rising,Michael Landreh,Jan Johansson,
ADVANCED FUNCTIONAL MATERIALS (2024)
EMBO molecular medicineno. 4 (2024): 715-716
NEURAL REGENERATION RESEARCHno. 11 (2024): 2343-2344
Nature Communicationsno. 1 (2024): 1-10
Journal of pediatric rehabilitation medicineno. 2 (2024): 253-260
Laurène Adam,Rakesh Kumar,Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp,Jan Stanislaw Nowak, Hannah Klute,Azad Farzadfard, Rami Alkenayeh,Janni Nielsen,Henrik Biverstål,Daniel E Otzen,Jan Johansson,
Protein science : a publication of the Protein Societyno. 8 (2024): e5091-e5091
Journal of pharmaceutical and biomedical analysis (2023): 115465-115465
Nephrology Dialysis Transplantationno. Supplement_1 (2023)
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