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The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
Research Interests
Papers共 382 篇Author StatisticsCo-AuthorSimilar Experts
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Ze Tian,Chunhua Shi, Guojun Yang,Jason K. Allen, Qing Shi, Amin AL-Shami, Jill Wardell Olson,Melinda G. Smith,Qing Chang,Jasbir Kaur,Junping You,Timothy E. Lofton,
LEUKEMIAno. 1 (2024): 226-226
Jeffrey Molldrem, Hong He, Rolando Vedia,Sijie Lu, Qiaochuan Li,Kathryn Cox, Lisa St John,Anna Sergeeva,Karen Clise-Dwyer,Gheath Alatrash,Elizabeth Shpall,Qing Ma
Research square (2024)
crossref(2023)
Jason Allen,Michelle Gonzalez,Jasbir Kaur, Melinda Smith,Junping You,Guojun Yang,Dongxing Zha, Ze Tian, Amin Al-Shami,Chunhua Shi,Jeffrey Molldrem,Tim Heffernan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
crossref(2023)
Robert Jenq,Eiko Hayase,Tomo Hayase,Akash Mukherjee, Stuart Stinson,Mohamed Jamal, Miriam Ortega,Christopher Sanchez,Saira Ahmed,Jennifer Karmouch,Chia-Chi Chang,Ivonne Flores,
Research Square (Research Square) (2023)
Mao Zhang,Pariya Sukhumalchandra, Atim A. Enyenihi,Lisa S. St. John,Sally A. Hunsucker,Elizabeth A. Mittendorf,Anna Sergeeva,Kathryn Ruisaard,Zein Al-Atrache, Patricia A. Ropp, Haroon Jakher, Tania Rodriguez-Cruz,
crossref(2023)
Clinical Cancer Research (2023)
Tapan M. Kadia,Hagop Kantarjian,Gheath Alatrash,Anna Sergeeva,Hong He,Lisa St John,Priya Koppikar,Celine Kerros,Abhishek Maiti,Courtney Dinardo, Elias Jabbour, Serge Vesrstovsek,
CANCER RESEARCHno. 8 (2023): CT101-CT101
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