基本信息
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Bio
Dr. Gillespie is an evolutionary biologist with broad interests in organismal and molecular evolution. The major focus of his current research is deciphering the mechanisms by which obligate intracellular species of Rickettsiales (Alphaproteobacteria) invade, survive and replicate within eukaryotic cells.
In research funded by the National Institutes of Health, Dr. Gillespie utilizes phylogenetics, comparative genomics and bioinformatics to guide experimental studies on various pathogenic species of Rickettsia and their associated arthropod vectors. His early research resulted in the reclassification of Rickettsia species and the identification of many lineage-specific pathogenicity factors. Through years of intense scrutinization of dozens of diverse rickettsial genomes, Dr. Gillespie and colleagues have described a large, dynamic mobilome for Rickettsia species, resulting in the identification of integrative conjugative elements as the vehicles for seeding Rickettsia genomes with many of the factors underlying obligate intracellular biology and pathogenesis. Via an iterative process of genome sequencing, phylogenomics, bioinformatics, and classical molecular biology and microbiology, Dr. Gillespie continues to lead and assist research projects on the characterization of rickettsial gene and protein function.
A particular focal area of Dr. Gillespie’s research is the Rickettsia secretome, which includes the secretion systems and their cognate substrates, many of which directly engage arthropod and vertebrate molecules throughout the rickettsial infection process. Dr. Gillespie led a study that identified across all genera of Rickettsiales the composition of an enigmatic type IV secretion system (T4SS), termed rvh (Rickettsiales vir homolog). Several collaborative efforts have begun elucidating the odd architecture of the rvh T4SS, as well as the protein substrates it translocates into host cells during infection. Dr. Gillespie is currently a co-Principal Investigator on a National Institutes of Health award to decipher the structure and function of the rvh T4SS.
Research Interests
Papers共 82 篇Author StatisticsCo-AuthorSimilar Experts
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MSPHEREno. 2 (2024): e0060923-e0060923
MBIOno. 5 (2024): e0075923-e0075923
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
FRONTIERS IN MICROBIOLOGY (2023): 1116766
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Author Statistics
#Papers: 81
#Citation: 5455
H-Index: 36
G-Index: 70
Sociability: 6
Diversity: 3
Activity: 14
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