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Bio
Dr. Garcia’s expertise extends to the genetic basis of inflammatory lung disease, with a particular focus on health disparities, as well as the mechanistic understanding of lung vascular permeability. Through bench-to-bedside approaches, his laboratory has conducted innovative research to develop methods aimed at preventing vascular leak, restoring endothelial cell barrier function, and maintaining vascular integrity.
Given their deep knowledge of lung inflammation and vascular permeability, Dr. Garcia’s lab has also explored the role of lung vasculature in the development of lung metastases. Leveraging their expertise in genomics, they have identified vascular genes that are crucial participants in both inflammatory lung injury and cancer development. Their investigations have led to the development of lung endothelial inflammatory gene expression profiles and diagnostic gene signatures influenced by key genes such as MYLK and NAMPT, which have implications for lung and breast cancer prognosis.
Furthermore, their work with NAMPT has resulted in the development of a therapeutic NAMPT neutralizing antibody. This antibody has shown promise in treating various cancers, including lung cancer, melanoma, and chronic lymphocytic leukemia.
Additionally, Dr. Garcia’s laboratory is actively involved in studying the adverse effects of thoracic radiation and exploring strategies to mitigate radiation-induced pneumonitis, fibrosis, and vascular leak.
Given their deep knowledge of lung inflammation and vascular permeability, Dr. Garcia’s lab has also explored the role of lung vasculature in the development of lung metastases. Leveraging their expertise in genomics, they have identified vascular genes that are crucial participants in both inflammatory lung injury and cancer development. Their investigations have led to the development of lung endothelial inflammatory gene expression profiles and diagnostic gene signatures influenced by key genes such as MYLK and NAMPT, which have implications for lung and breast cancer prognosis.
Furthermore, their work with NAMPT has resulted in the development of a therapeutic NAMPT neutralizing antibody. This antibody has shown promise in treating various cancers, including lung cancer, melanoma, and chronic lymphocytic leukemia.
Additionally, Dr. Garcia’s laboratory is actively involved in studying the adverse effects of thoracic radiation and exploring strategies to mitigate radiation-induced pneumonitis, fibrosis, and vascular leak.
Research Interests
Papers共 882 篇Author StatisticsCo-AuthorSimilar Experts
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Carrie L Kempf,Jin H Song,Saad Sammani,Tadeo Bermudez,Vivian Reyes Hernon,Lin Tang,Hua Cai,Sara M Camp, Carly A Johnson, Mohamed S Basiouny,Leslie A Bloomquist,Jacqueline S Rioux,
European journal of respiratory medicineno. 1 (2024): 389-397
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PNAS NEXUSno. 5 (2024): pgae173-pgae173
ANNUAL REVIEW OF PHYSIOLOGY (2024): 505-529
Lei Gao,Francisco J. Ramirez,Jody Tori O. Cabrera,Mathews V. Varghese,Makiko Watanabe,Atsumi Tsuji-Hosokawa,Qiuyu Zheng, Mingya Yang,Md Rahatullah Razan,Carrie L. Kempf,Sara M. Camp, Jian Wang,
Diabetologiapp.1-14, (2024)
Zhonglin Liu,Saad Sammani,Christy J. Barber,Carrie L. Kempf,Feng Li,Zhen Yang, Rosendo T. Bermudez,Sara M. Camp, Vivian Reyes Herndon,Lars R. Furenlid,Diego R. Martin,Joe G. N. Garcia
BIOMEDICINE & PHARMACOTHERAPY (2024): 116103-116103
JOURNAL OF HEART AND LUNG TRANSPLANTATIONno. 5 (2024): 755-770
Melissa D Halpern,Akash Gupta,Nahla Zaghloul, Senthilkumar Thulasingam,Christine M Calton,Sara M Camp,Joe G N Garcia, Mohamed Ahmed
Biomedicinesno. 5 (2024): 970
Pulmonary circulationno. 1 (2023)
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