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Research Interests: The central theme of Dr. Frydman’s research is to understand how cells maintain a healthy and functional proteome by focusing on biological mechanisms controlling cellular protein folding, aggregation and quality control. Her research has made important contributions to understanding protein homeostasis (proteostasis) in eukaryotic cells. Her lab discovered that distinctly regulated proteostasis networks mediate cotranslational folding and protection of the proteome from proteotoxic stress. She also established the key role of spatial sequestration of misfolded and aggregated proteins in specific membrane-less cellular compartments in proteome quality control and defined how chaperone-dependent pathways cooperate with specific components of the ubiquitin-proteasome system to mediate cytoplasmic and nuclear misfolded protein quality control. Work in the Frydman lab has also identified specific interventions that disfavor the production of toxic protein species; efforts are now focused on the link between aging and loss of cellular robustness. Her lab harnesses these insights to develop therapeutic approaches to ameliorate human diseases including neurodegenerative and viral infectious diseases.
研究兴趣
论文共 223 篇作者统计合作学者相似作者
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Yingli Gu,Alexander Pope,Charlene Smith,Christopher Carmona,Aaron Johnstone,Linda Shi,Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes,Thomas Shoff, Korbin M. Kleczko,Judith Frydman,
Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A. Opoku-Nsiah, Alexander Leitner,Judith Frydman,Soung-Hun Roh
Ranen Aviner,Peter V. Lidsky,Yinghong Xiao,Michel Tassetto, Damian Kim, Lichao Zhang, Patrick L. Mcalpine, Joshua Elias,Judith Frydman,Raul Andino
PLOS PATHOGENSno. 2 (2024): e1011535-e1011535
Domenico Di Fraia, Antonio Marino,Jae Ho Lee,Erika Kelmer Sacramento, Mario Baumgart,Sara Bagnoli, Pedro Tomaz da Silva, Amit Kumar Sahu,Giacomo Siano, Max Tiessen, Eva Terzibasi-Tozzini,Julien Gagneur,
bioRxiv : the preprint server for biology (2024)
Benjamin M. Moran,Cheyenne Y. Payne,Daniel L. Powell,Erik N. K. Iverson, Alexandra E. Donny,Shreya M. Banerjee,Quinn K. Langdon,Theresa R. Gunn, Rebecca A. Rodriguez-Soto, Angel Madero,John J. Baczenas, Korbin M. Kleczko,
Natureno. 7997 (2024): 119-127
Karen Betancourt Moreira,Miranda P. Collier,Alexander Leitner,Kathy H. Li, Ivana L. Serrano Lachapel, Frank Mccarthy, Kwadwo A. Opoku-Nsiah,Fabian Morales-Polanco,Natalia Barbosa,Daniel Gestaut,Rahul S. Samant,Soung-hun Roh,
Domenico Di Fraia,Antonio Marino,Jae Ho Lee,Erika Kelmer Sacramento,Mario Baumgart,Sara Bagnoli, Pedro Tomaz da Silva,Amit Kumar Sahu,Giacomo Siano, Max Tiessen,Julien Gagneur,Judith Frydman,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Cancer Researchno. 8_Supplement (2023): LB075-LB075
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