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My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer. As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical. Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.
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Nicholas P. Lockyer,Satoka Aoyagi,John S. Fletcher, Ian S. Gilmore, Paul A. W. van der Heide,Katie L. Moore,Bonnie J. Tyler, Lu-Tao Weng
Nature Reviews Methods Primersno. 1 (2024): 1-21
Noora Neittaanmäki,Oscar Zaar, Kevin Sjögren Cehajic, Kelly Dimovska Nilsson,Dimitrios Katsarelias, Roger Olofsson Bagge, John Paoli,John S Fletcher
Pigment cell & melanoma research (2024)
Nicholas P. Lockyer,Satoka Aoyagi,John S. Fletcher,Ian S. Gilmore, Paul A. W. van der Heide, Katie L. Moore,Bonnie J. Tyler, Lu-Tao Weng
Nature Reviews Methods Primersno. 1 (2024)
Surface and Interface Analysisno. 12 (2020): 1006-1012
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