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Genetic decoding is dynamic. It can be altered in an mRNA- or site-specific manner and in a remarkable variety of ways. The meaning of individual codons can be redefined in response to signals in mRNA. A proportion of translating ribosomes can be diverted at a specific site to a different reading frame. They can also be directed to bypass a block of nucleotides - at least up to 50 - or even to resume on a different mRNA. We are studying these "recoding" phenomena to determine where they occur, understand their functional significance, elucidate the mechanisms involved, and where desirable plot intervention strategies.
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论文共 364 篇作者统计合作学者相似作者
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Acta Crystallographicano. a1 (2023): A132-A132
Nature Communicationsno. 1 (2023): 1095-9
NATUREno. 7945 (2023): 631-632
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2023): e2221683120-e2221683120
Natureno. 7906 (2022): E16-E23
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#Papers: 348
#Citation: 22115
H-Index: 82
G-Index: 137
Sociability: 7
Diversity: 0
Activity: 1
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