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Bio
My research projects focus on three areas of lung development and lung disease in premature infants. The first of these is the study of lung surfactant associated proteins that are essential for normal lung function and preventing collapse. Most premature infants borne 6 or more weeks early are deficient or lacking the most essential surfactant protein referred to as SP-B and must be given surfactant mixtures derived from cow or pig lungs. The goal of research is to establish alternative approaches that would allow the baby to produce its own surfactant and make use of animal derived products unnecessary. A second area of research is the study of oxygen-sensing proteins/pathways and related metabolic pathways in alveolar cells and responses to low oxygen tensions observed during lung development or lung collapse. A very unique discovery by our lab is that a the alveolar cells responsible for production of surfactant produce hemoglobin when exposed to conditions of low oxygen-including during lung development or as a result of specific lung diseases or lung collapse. We aim to determine the role of this hemoglobin in surfactant production by these cells. The third area of research in my lab focuses on the production of bioengineered scaffolds for culture of isolated primary cells in single or multi-cell type culture to mimic regeneration of lung tissue. This approach also allows very specialized studies required for the projects mentioned above. Most experiments designed to study lung health require the use of animal models or cell models that approximate human disease or development. To overcome this obstacle, we have developed a novel human lung tissue cryopreservation method that yields viable lung tissue and viable primary cells post thaw. This technique will allow us to expand our research beyond animal and cell culture models, thereby permitting specific examination of human lung development or disease.
Research Interests
Papers共 130 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of women's health (2002)no. 7 (2024): 887-900
The American Journal of the Medical Sciences (2024): S408
Megan D Rodgers, Molly J Mead,Caroline A McWhorter,Myla D Ebeling,Judy R Shary,Danforth A Newton,John E Baatz,Mathew J Gregoski,Bruce W Hollis,Carol L Wagner
Nutrientsno. 19 (2023): 4250-4250
AMERICAN JOURNAL OF PERINATOLOGYno. S 01 (2023): e2098-e2105
Food chemistry (2023): 138126-138126
The American Journal of the Medical Sciences (2023): S326-S326
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