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Research and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
Research Interests
Papers共 122 篇Author StatisticsCo-AuthorSimilar Experts
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Anna V. Elleman, Nikola Milicic,Damian J. Williams,Jane Simko,Christine J. Liu, Allison L. Haynes,David E. Ehrlich,Christopher D. Makinson,J. Du Bois
Cell Chemical Biologyno. 7 (2024): 1324-1335.e20
STAR PROTOCOLSno. 1 (2024): 102792-102792
Mengyuan Xu, Torben Neelands, Alexander S. Powers, Yan Liu, Steven D. Miller, Grigore Pintilie,J. Du Bois,Ron O. Dror,Wah Chiu,Merritt Maduke
biorxiv(2023)
Husniye Kantarci, Pablo D. Elvira,Arun P. Thottumkara,Manasi Iyer,Lauren J. Donovan, Micaela Quinn Dugan,Nicholas Ambiel,Emma M. O’Connell,Alejandro Granados,Hong Zeng,Nay L. Saw,Amanda Brosius Lutz,
biorxiv(2023)
Anna V. Elleman, Nikola Milicic,Damian J. Williams,Christine J. Liu, Allison L. Haynes,Jane Simko,David E. Ehrlich,Christopher D. Makinson,J. Du Bois
Cell Chemical Biology (2023)
Cell chemical biologyno. 4 (2021): 615-624.e5
bioRxiv (Cold Spring Harbor Laboratory) (2020)
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