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The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
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论文共 133 篇作者统计合作学者相似作者
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MOLECULAR CELLno. 3 (2024): 584-595.e6
The Journal of general virologyno. 10 (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
medRxiv : the preprint server for health sciences (2023)
BIOPHYSICAL JOURNALno. 3 (2022): 33-33
biorxiv(2021)
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