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We investigate the mechanisms of oxygenases, the enzymes nature uses to catalyze the incorporation of oxygen into biological molecules. Oxygen incorporation reactions are important for a wide variety of reasons, ranging from activation of steroid hormones in humans to the detoxification of compounds in the environment. The oxygenases we study contain a metal which is the key to the chemistry they catalyze. Enzyme mechanisms involve both the chemical reactions occurring at the active site and the regulation of the reaction imposed by the complex protein structure. Consequently, we use many types of biochemical and physical techniques including transient kinetics, site directed mutagenesis, diagnostic substrate reactions, and EPR spectroscopy. This is extended to X-ray crystallography and other spectroscopies through collaborations.
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Journal of the American Chemical Societyno. 28 (2023): 15230-15250
John C. Lipscomb, Christopher L. Kuhlman
Toxicological Risk Assessment and Multi-System Health Impacts from Exposurepp.163-174, (2021)
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