基本信息
浏览量:41
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My main goal in science is to understand how usually harmless colonizing bacteria of the upper respiratory tract are able to cause inflammatory diseases that include otitis media, pneumonia and sepsis. Both host factors such as the complement system and bacterial virulence mechanisms have my interest.
In the last years, I have used bacterial genome-wide mutagenesis screens to identify the genetic architecture needed for non-typeable Haemophilus influenzae to survive in the presence of an active complement system, survive in the presence of phagocytizing neutrophils and the ability to form biofilms.
Currently, I use genome-wide mutagenesis screens to identify bacterial genes required to grow in nutrient poor conditions such as the lungs. Current studies most often use growth medium rich in nutrients, though, this is not a natural environment. Therefore, I study bacterial growth on polarized primary human epithelial cells. In this model, I wish to identify bacterial mechanisms that are required for nutrient take-up, but also for survival in the presence of antimicrobial activity of the mucus layer.
My ultimate goal is to understand bacterial pathogenesis and contribute to the development of a vaccine or small molecule inhibitor that prevents or treat inflammatory diseases.
研究兴趣
论文共 86 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
EBIOMEDICINE (2023): 104868-104868
Manon Beaujean,Rienke F Uijen,Jeroen D Langereis,David Boccara, Denise Dam,Angèle Soria, Gert Veldhuis,Lucille Adam,Olivia Bonduelle,Nicole N van der Wel,Joen Luirink,Eric Pedruzzi,
Vaccineno. 13 (2023): 2270-2279
加载更多
作者统计
#Papers: 88
#Citation: 1543
H-Index: 24
G-Index: 34
Sociability: 6
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn