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Bio
Julio C. Tapia is a Chilean Biochemist, PhD in Biomedical Sciences. He performed his PhD thesis in laboratory of Prof. Jorge E. Allende on the structure-function of the protein kinase CK2. In doing so, he also performed two long working-stays with the world leader in structural biology, Prof. Tom Blundell, at the Department of Biochemistry, University of Cambridge, UK. Dr. Tapia was PI in a Doctoral Fondecyt grant whose findings were published in four international journals. He was a postdoc fellow at the Center for Molecular Studies of the Cell (CEMC), Faculty of Medicine, University of Chile (UCH), where executed as PI a Postdoc Fondecyt grant whose findings were reported in three international journals.
In 2008, Dr. Tapia got an academic position as Assistant Professor at the Cell & Molecular Biology Program, Institute of Biomedical Sciences (ICBM) in UCH, and developed as PI an Initiation Fondecyt grant, stablishing his research group “Cell Transformation Lab”, whose interests are the molecular and cellular mechanisms regulated by CK2 promoting tumorigenesis and metastasis of colorectal and other cancers. In 2012, Dr. Tapia was upgraded to Associate Professor at UCH. As PI, he has executed one ICGEB grant and three Regular Fondecyt grants, as well as he has been co-investigator in one Anillo grant and other six Regular Fondecyt grants.
In 2022, Dr. Tapia was upgraded to Full Professor at UCH. His group has published in Q1/Q2 international cancer-related journals, including PNAS USA, Molecular Oncology, Cancers, Molecular Cancer, Oncotarget, Cell Death & Disease, Frontiers in Oncology, and Cancer Letters. They have reported the CK2-dependent regulation of several signaling pathways including Wnt/b-catenin, PI3k/Akt/mTORC1 and currently the Endothelin-1 axis. Between their more recent results highlight the methuosis-like death of colorectal cancer cells by the CK2 inhibitor silmitasertib, and the role of the endothelin-converting enzyme-1c (ECE-1c) in acquisition of malignant traits in colorectal and other cancer cells. To date, he has mentored 15 undergraduate, 17 graduate students, and one postdoc fellow. He is one of the main founders of the Center for Cancer Research and Treatment (CITC, UCH), Director for Santiago and current Secretary of the Chilean Society for Biochemistry and Molecular Biology (SBBMCh), ex-member of the Committee of PhD in Biomedical Sciences at UCH (past director), and founder member of the Iberoamerican Network of Aptamers (REDIBA).
Research Interests
Papers共 80 篇Author StatisticsCo-AuthorSimilar Experts
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International Journal of Molecular Sciencesno. 12 (2024): 6740
Edio Maldonado, Paz Canobra, Matías Oyarce,Fabiola Urbina,Vicente J Miralles,Julio C Tapia,Christian Castillo,Aldo Solari
Microorganismsno. 5 (2024): 907
Ignacio Niechi,Jose I. Erices,Diego Carrillo-Beltran,Atenea Uribe-Ojeda,Angelo Torres,Jose Dellis Rocha,Daniel Uribe, Maria A. Toro, Karla Villalobos-Nova,Belen Gaete-Ramirez,Gabriel Mingo,Gareth I. I. Owen,
CELLSno. 3 (2023): 506-506
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 22 (2023): 16076-16076
Francisco Rodas, Jetzabel A. Vidal-Vidal, Daniela Herrera, David A. Brown-Brown, Diego Vera, Joaquín Veliz, Pilar Püschel,José I. Erices, Verónica Sánchez Hinojosa,Julio C. Tapia,Eduardo Silva-Pavez,Claudia Quezada-Monrás,
Cancer Cell Internationalno. 1 (2023): 1-13
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 23 (2022): 15418-15418
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Author Statistics
#Papers: 78
#Citation: 1965
H-Index: 24
G-Index: 43
Sociability: 6
Diversity: 3
Activity: 32
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