基本信息
views: 5
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Realizing the few options available for kidney cancer patients, Dr. Brugarolas decided to dedicate his life to finding a cure. Following completion of medical school in his home country of Spain in 1993, he came to the U.S. seeking to better understand the biological underpinnings of cancer. As a graduate student at MIT, his research in the laboratory of Tyler Jacks, Ph.D. provided fundamental understanding on how cell proliferation is regulated by both external and internal cues. In a series of highly-cited manuscripts in Nature, Proceedings of the National Academy of Sciences, and The Journal of Cell Biology, he reported that growth signals control the cell cycle by modulating the activity of CDK4 and CDK2, and that constitutive activation of these kinases was sufficient to confer cell proliferation autonomy. His studies revealed that the so-called guardian of the genome, the p53 protein, imposed a cell cycle arrest through p21, but that p21 was dispensable for p53-mediated cell death, and provided insight into the mechanism of p21 action.
Research Interests
Papers共 336 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
crossref(2024)
crossref(2024)
crossref(2024)
Dylan Calhoon, Lingjie Sang,Divya Bezwada, Nathaniel Kim,Amrita Basu, Sheng-Chieh Hsu, Anastasia Pimentel,Bailey Brooks,Konnor La, Ana Paulina Serrano, Daniel L Cassidy,Ling Cai,
biorxiv(2024)
ArXiv (2024)
Cited0Views0WOSEIBibtex
0
0
crossref(2024)
crossref(2024)
Dazhi Wang,Iqbal Mahmud, Vijay S. Thakur,Sze Kiat Tan, Daniel G. Isom, David B. Lombard,Mark L. Gonzalgo, Oleksandr N. Kryvenko,Philip L. Lorenzi,Vanina T. Tcheuyap,James Brugarolas,Scott M. Welford
crossref(2024)
Load More
Author Statistics
#Papers: 343
#Citation: 14704
H-Index: 56
G-Index: 120
Sociability: 7
Diversity: 0
Activity: 4
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn