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个人简介
Among his landmark achievements, Dr. Roth was principal investigator for the first tumor suppressor gene therapy clinical trials approved by the National Institutes of Health Recombinant DNA Advisory Committee and the U.S. Food and Drug Administration. Approval for those historic protocols was based on his demonstrating feasibility and efficacy through laboratory and preclinical studies. His team showed that restoration of function for a single normal tumor suppressor gene could mediate regression of human cancers in vivo, helped identify and characterize a number of novel tumor suppressor genes on chromosome 3, and found that systemic delivery of tumor suppressor genes using a nanoparticle vector could effectively treat disseminated human lung cancer in animal models. These observations led Dr. Roth and colleagues to initiate the first clinical trial using nanoparticles to deliver genes systemically. Cancer gene therapy developed in his laboratory became the first gene therapy to be approved for human use. In addition to being an international leader in developing gene therapy for lung and other cancers, he has trained a new generation of outstanding surgical oncologists and laboratory researchers who are applying his philosophy of excellence throughout the world.
研究兴趣
论文共 648 篇作者统计合作学者相似作者
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Haniel A Araujo, Ximo Pechuan-Jorge, Teng Zhou,Minh Truong Do, Xin Hu, Frank R Rojas Alvarez, Maria E Salvatierra, Heladio P Ibarguen, Richard Lee, Rashi Raghulan, Harshit Shah, Mariela A Moreno Ayala,
Cancer discovery (2024)
JOURNAL OF SURGICAL ONCOLOGYno. 2 (2024): 331-337
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus (2024)
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 1 (2024): 329-337.e4
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 4 (2024): 1444-1453.e4
Funda Meric-Bernstam, Michael W. Lloyd,Soner Koc,Yvonne A. Evrard,Lisa Meier. McShane,Michael T. Lewis,Kurt W. Evans,Dali Li,Lawrence V. Rubinstein,Alana L. Welm, Dennis A. Dean,Anuj Srivastava,
Funda Meric-Bernstam, Michael W Lloyd,Soner Koc,Yvonne A Evrard,Lisa Meier McShane,Michael T Lewis,Kurt W Evans,Dali Li,Lawrence V Rubinstein,Alana L Welm, Dennis A Dean,Anuj Srivastava,
Molecular cancer therapeutics (2024)
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