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Gustafsson et al cloned the first (partial) cDNA of a nuclear receptor, the glucocorticoid receptor; the unique probes making this possible were the poly- and monoclonal antibodies against the glucocorticoid receptor developed by the Gustafsson lab. Another important milestone was the structure determination of the DNA-binding domain of the glucocorticoid receptor, the first ever nuclear receptor structure to be solved. During the recent fifteen years, Gustafsson has continued to be responsible for paradigm shifts in the field of nuclear receptor research. It was Gustafsson who first identified physiological ligands for a so called “orphan receptor”, namely fatty acids for the peroxisome proliferator activated receptor (PPAR), thereby integrating fatty acids into molecular endocrinology. Furthermore, Gustafsson discovered OR-1, later renamed LXRβ, an oxysterol activated nuclear receptor of paramount significance in e g regulation of cholesterol homeostasis and brain development.
Finally, and most importantly, Gustafsson and colleagues made the completely unexpected discovery of estrogen receptor β, a second estrogen receptor which has turned out to have functions far outside reproductive physiology and to be a very promising target in pharmaceutical development of novel drugs.
Finally, and most importantly, Gustafsson and colleagues made the completely unexpected discovery of estrogen receptor β, a second estrogen receptor which has turned out to have functions far outside reproductive physiology and to be a very promising target in pharmaceutical development of novel drugs.
Research Interests
Papers共 1222 篇Author StatisticsCo-AuthorSimilar Experts
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Receptorsno. 3 (2024): 304-322
Dongfang Wang, Muya Tang,Peidong Zhang,Kailin Yang,Liang Huang,Mengrui Wu,Qiuhong Shen,Jing Yue,Wei Wang,Yanqiu Gong,Margaret Warner,Lunzhi Dai,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 13 (2024): e2306814121-e2306814121
International journal of biological sciencesno. 9 (2023): 2848-2859
Savini Thrikawala,Fahmi Mesmar, Beas Bhattacharya,Maram Muhsen,Srijita Mukhopadhyay,Sara Flores, Sanat Upadhyay,Leoncio Vergara,Jan-Ake Gustafsson,Cecilia Williams,Maria Bondesson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 15 (2023)
Receptorsno. 3 (2023): 176-190
International journal of molecular sciencesno. 6 (2023): 5867-5867
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