基本信息
浏览量:0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
I am interested in studying the molecular and signal transduction mechanisms of G-protein coupled receptors that modulate renal and bone physiopathology. My research career is focused on the parathyroid hormone (PTH) receptor (PTHR) and associated proteins aiming to elucidate the molecular mechanisms that regulate processes of kidney fibrosis and bone osteoporosis/aging and to develop new therapeutic approaches for translational medicine applications.
I graduated in Biological Sciences at Complutense Universtity of Madrid in 2003.
During my degree I collaborated with Dr. Moreno Díaz de la Espina from the CIB (CSIC) on the analysis of nuclear organization and functions, and obtained a collaboration fellowship in the Department of Animal Physiology (Complutense Universtity of Madrid). In 2003 I joined Dr. Esbrit research group at Jiménez Díaz Foundation and focused my thesis on the molecular mechanisms triggered by PTHR signaling in acute and chronic kidney disease. These studies allowed us to discover the role of a protein that interacts with the PTHR, parathyroid hormone-related protein (PTHrP), in promoting renal fibrosis and epithelial mesenchymal transition and publish in several top journals in the field. This work opened the path to the
development of novel renal therapies and was awarded with the Renal Basic Research award by the Iñigo Alvarez de Toledo Renal Foundation in 2006.
I received the PhD in Biochemistry, Molecular Biology and Biomedicine (Universidad Autonoma de Madrid) in 2008 and my thesis research was awarded with the Extraordinary Thesis Award by the Jiménez Díaz Foundation in 2009.
After completing my PhD I joined Dr. Friedman’s laboratory in the Pharmacology
and Chemical Biology Department at the University of Pittsburgh (Pennsylvania, USA) as a postdoctoral associate. In Pittsburgh I specialized in state-of-the art fluorescence microscopy techniques of live cell imaging including Fluorescence Resonance Energy Transfer (FRET), Total Internal Reflection Fluorescence (TIRF), Fluorescence Recovery After Photobleaching (FRAP)… Using these techniques we discovered a new naturally occurring isoform of PTHR (Δe14-PTHR) that inhibits trafficking and signaling of PTHR. Also, we described PTHR-dependent cAMP production in intracellular compartments. This new concept published in Nature Chemical Biology questions the traditional knowledge based on that cAMP production triggered by receptors originates exclusively at the cell membrane. In 2012 I was appointed Adjunct Research Instructor in Pharmacology and Chemical Biology at the School of Medicine,University of Pittsburgh.
From 2012 to 2015 I worked at Jimenez Diaz Foundation with a Juan de la Cierva postdoctoral appointment. With the help of my co-workers I implemented Fluorescence Microscopy and Live Cell Imaging Techniques to different lines of research developed in Fundación Jiménez Díaz including the study of PTHR signaling in bone osteoporosis and aging.
Since 2015 I have been a professor in the School of Medicine, San Pablo CEU University and principal investigator of the bone physiopathology laboratory. Currently my research aims to study PTH1R actions on the communication between bone cells and bone metastatic cells supported by grants from the Spanish Ministry of Science and Innovation.
研究兴趣
论文共 70 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alvaro Tablado Molinera, Irene Gutierrez Rojas,Luis Alvarez Carrion, Irene Tirado Cabrera,Sara Heredero-Jimenez,Arancha R. Gortazar,Juan Antonio Ardura
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERALno. 1 (2023): 21-28
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERALno. 1 (2023): 12-20
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn