Dr. Lossos' laboratory is investigating pathogenesis of different subtypes of non Hodgkin's lymphomas as well as novel therapeutic approaches. Specific interests are in: 1) Function of the HGAL gene in lymphoma dissemination and BCR signaling; 2) Role of LMO2 protein in pathogenesis of DLBCL; 3) Alterations in DNA repair mechanisms in lymphoma; 4) pathogenesis of orbital marginal zone lymphomas; and 5) Function and targeting of PRMT5 protein in DLBCL.