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Bio
The research of prof. De Esch aims to understand and predict interactions between biologically active substances and their molecular targets, such as receptors and enzymes. The group makes extensive use of Computer-Aided Drug Design (CADD) approaches and structural biology insights. New ligands are designed and synthesized in the organic chemistry laboratories that are equipped with state-of-the-art synthesis equipment and all the necessary analytical chemistry tools. The group is developing and using Fragment-Based Drug Design (FBDD) approaches as this represents an exciting, highly efficient and design-intensive approach that can be applied to many different molecular targets. Various protein classes are being interrogated, including, amongst others, GPCRs, PDEs, AChBP and LGICs, protein-protein interactions, kinases and others. Next to hit finding, the group has ample experience in hit and lead optimization that results in pre-clinical drug candidates that are studied in various disease models within the research institute AIMMS, the VU University Medical Center Amsterdam and various (inter)national collaborations.
Research Interests
Papers共 268 篇Author StatisticsCo-AuthorSimilar Experts
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Aurelien M. Zarca, Ilze Adlere, Cristina P. Viciano, Marta Arimont-Segura,Max Meyrath,Icaro A. Simon,Jan Paul Bebelman, Dennis Laan,Hans G. J. Custers,Elwin Janssen, Kobus L. Versteegh, Maurice C. M. L. Buzink,
MOLECULAR PHARMACOLOGYno. 4 (2024): 301-312
Sophie Bérenger, Justyna M. Adamska,Francesca Deflorian,Chris de Graaf,Christie B. Palmer,Martyna Szpakowska,Andy Chevigné,Iwan J. P. de Esch,Barbara Zarzycka,Henry F. Vischer,Maikel Wijtmans,Rob Leurs
biorxiv(2024)
JOURNAL OF MEDICINAL CHEMISTRYno. 4 (2024): 2287-2304
PLoS neglected tropical diseasesno. 11 (2023): e0011760-e0011760
Journal of medicinal chemistryno. 15 (2023): 10252-10264
NUCLEAR MEDICINE AND BIOLOGY (2023): S144-S145
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