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We study cell-cell interactions, signal transduction, and cell fate specification during C. elegans development. Much of our work is centered on LIN-12/Notch, the receptor component of a major signaling system for specifying cell fate during animal development. In addition, mutations in core components and modulators of the LIN-12/Notch pathway have been implicated in cancer, Alzheimer's disease, and other diseases and syndromes. Using C. elegans, we study how LIN-12/Notch signaling is modulated during normal development and identify potential ways it may be modulated to combat disease.
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Developmental cellno. 5 (2017): 542-553.e4
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