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个人简介
Dr. Irwin “Irv” Bernstein studies how stem cells in the bone marrow form, mature and give rise to all the cells of a person’s blood and immune system. His longstanding goal has been to translate laboratory discoveries into new therapies for people with leukemia and other diseases. An example is the first-ever “magic bullet” drug, or antibody-drug conjugate: gemtuzumab ozogamicin (Mylotarg). The leukemia drug was based on Dr. Bernstein’s fundamental research on blood cell biology, and he was one of its lead developers. His team has also learned how a set of signals called the Notch pathway prompt blood stem cells to multiply. A Fred Hutch spinoff, Nohla Therapeutics, is now building on this discovery to develop off-the-shelf, universal-donor cell therapies. Dr. Bernstein also leads federally funded research training programs for early career scientists at Fred Hutch. For more than 40 years, Dr. Bernstein headed the Pediatric Oncology Program at Fred Hutch and the Division of Hematology and Oncology in the UW Department of Pediatrics.
研究兴趣
论文共 307 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2023)
Samantha Kaonis,Jenny L Smith,Neerja Katiyar, Morgan Merrill, Tiffany Hyelkma,Stephanie Namciu,Quy Le,Ekaterina Babaeva,Takashi Ishida,Shelli M Morris,Emily Girard, Suzanne Furuyama,
bioRxiv : the preprint server for biology (2023)
Nature Communicationsno. 1 (2022): 1584-17
Experimental Hematology (2022): S96-S96
CELL REPORTSno. 11 (2021)
Cell Reports (2021)
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作者统计
#Papers: 307
#Citation: 21477
H-Index: 73
G-Index: 142
Sociability: 7
Diversity: 3
Activity: 11
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