基本信息
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职业迁徙
个人简介
In my group we are interested in the role of autophagy in health and disease. Autophagy is an evolutionarily conserved catabolic process that involves the degradation of cytoplasmic material through the lysosomal pathway. Autophagy is a cellular response in nutrient starvation but it is also responsible for the removal of aggregated proteins, damaged organelles and developmental remodeling. Recent studies have shown that dysfunction in autophagy has been implicated in an increasing number of diseases from bacterial and viral infections to cancer and more recently in neurodegeneration and other ageing-related diseases. Interestingly, it has been shown that induction of autophagy can increase longevity in multiple animal species. Although it was initially believed that autophagy occurs randomly inside the cell, during the last years there is growing evidence that sequestration and degradation of cytoplasmic material by autophagy can be selective through receptor and adaptor proteins. It is therefore important to identify the proteins required for recognition and targeting of the various autophagic cargo for degradation and to elucidate the role of selective autophagy in normal and pathological conditions, especially at the organismal level. We are using mammalian cells in vitro and the fruit fly Drosophila melanogaster, as a genetically modifiable model organism to investigate the mechanisms of autophagy in the context of the physiology of the cell, the system and the living organism. We have developed several molecular markers for monitoring autophagy in vivo.
The major aims of our research are:
To identify novel selective autophagy receptors and adaptors
To understand the cellular and molecular mechanisms of autophagy during ageing
To elucidate the cellular and molecular mechanisms of autophagy in diseases such as neurodegeneration, obesity, bacterial and viral infections and tumorigenesis
The long term goal of our research is to develop therapeutic strategies for these diseases.
研究兴趣
论文共 77 篇作者统计合作学者相似作者
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Holly Shropshire,Richard Guillonneau,Zengsheng Han,Rebekah A. Jones, Shadman Ahmed,Inmaculada García-Romero, Isabel Aberdeen,Ioannis Nezis,Miguel A. Valvano,David J. Scanlan,Yin Chen
biorxiv(2023)
Agathangelos Chatzichristofi, Vasileios Sagris, Aristos Pallaris,Marios Eftychiou,Ioanna Kalvari,Nicholas Price,Theodosios Theodosiou,Ioannis Iliopoulos,Ioannis P. Nezis,Vasilis J. Promponas
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Holly Shropshire,Richard Guillonneau,Zengsheng Han,Rebekah A. Jones, Salma Ahmed,Inmaculada García‐Romero, Isabel Aberdeen,Ioannis P. Nezis,Miguel A. Valvano,David J. Scanlan,Yin Chen
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Panagiotis Tsapras,Stavroula Petridi, Selina Chan, Marta Geborys,Anne-Claire Jacomin,Antonia P. Sagona, Pascal Meier,Ioannis P. Nezis
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作者统计
#Papers: 74
#Citation: 3866
H-Index: 31
G-Index: 61
Sociability: 5
Diversity: 3
Activity: 23
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