基本信息
浏览量:0
职业迁徙
个人简介
Research interests
Our laboratory investigates fundamental mechanisms of regulation of bacterial biofilm development with a focus on human pathogens. We are interested in understanding how signal transduction systems control the transition between planktonic and sessile lifestyles. We also study the composition of biofilm matrix and the function of these compounds during infection. In particular, we do research on basic principles of RNA overlapping transcription and its role in gene expression, on mechanisms of exopolysaccharide synthesis regulation and on how surface proteins of the biofilm matrix mediated intercellular adhesion and interactions with the host cells. Very recently, we have deconstructed the two-component signal transduction system of Staphylococcus aureus. In this study, we have generated fifteen S. aureusstrains, each containing just a single TCS, as well as a mutant lacking all 15 non-essential TCS. This powerful and unique genetic resource will allow us to unambiguously determine the contribution that each individual TCS to the regulation of peptidoglycan biosynthesis and antibiotic resistance.
研究兴趣
论文共 137 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature microbiologypp.1-13, (2024)
Pablo Iturbe, Alvaro San Martín, Hiroshi Hamamoto, Marina Marcet-Houben,Toni Galbaldón,Cristina Solano,Iñigo Lasa
microLife (2024): uqae007-uqae007
MICROORGANISMSno. 3 (2022): 600
NPJ BIOFILMS AND MICROBIOMESno. 1 (2022): 62-13
Karin Svensson Malchau, Jonatan Tillander,Magdalena Zaborowska, Maria Hoffman,Iñigo Lasa, Peter Thomsen,Henrik Malchau, Ola Rolfson,Margarita Trobos
International Microbiologyno. 4 (2021): 521-529
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn