基本信息
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Bio
The overarching theme of the research in this group is the investigation of the molecular mechanisms underlying chronic inflammation in severe asthma and COPD and how these processes are affected by oxidative stress and by corticosteroids. These studies are performed in both cultured and primary airway structural cells (epithelial cells and smooth muscle cells), T-cells and monocytes/macrophages, in human lung tissues and in animal models of disease. As a group we use molecular, pharmacological and histological techniques including reporter gene assays, overexpression, Western blotting, RT-qPCR, confocal imaging, chromatin immunoprecipitation, 3C analysis, transcriptomic analysis, SILAC/iTRAQ and siRNA. There is a major focus on translational research with the application of state-of-the-art molecular techniques to primary cells from patients with airways disease. We work closely with colleagues within other groups in Airways Disease such as Professor Chung (Severe Asthma), Professors Barnes and Donnelly (COPD) and Dr Usmani (Small Airways) to enable better translational research. We also collaborate with other researchers within NHLI to examine inflammatory responses to infections (Professor Johnston), in pulmonary hypertension (Dr Wort), in fibrosis (Dr Renzoni) and following heart surgery (Professor Angelini).
Research Interests
Papers共 1009 篇Author StatisticsCo-AuthorSimilar Experts
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EBIOMEDICINE (2024): 104936-104936
Reference Module in Biomedical Sciences (2024)
Rosa Peltrini,Rebecca L Cordell,Michael Wilde, Shahd Abuhelal, Eleanor Quek, Nazanin Zounemat-Kermani,Wadah Ibrahim,Matthew Richardson,Paul Brinkman,Florence Schleich,Pierre-Hugues Stefanuto, Hnin Aung,
American journal of respiratory and critical care medicine (2024)
Akshaya Keerthi Saikumar Jayalatha, Marlies E Ketelaar,Laura Hesse,Yusef E Badi, Nazanin Zounemat-Kermani, Brouwer Sharon,Nicole F Dijk,Maarten van den Berge,Victor Guryev,Ian Sayers,Judith E Vonk,Ian M Adcock,
The European respiratory journal (2024)
Lungno. 1 (2024): 41-51
Francesco Nucera, Letterio Bonina, Antonino Cipolla, Pietro Pirina,Philip M Hansbro,Ian M Adcock,Gaetano Caramori
Advances in experimental medicine and biology (2024): 183-204
International Immunopharmacology (2024): 112419-112419
Jiali Weng, Qi Liu,Chenfei Li,Yi Feng,Qing Chang,Meiqin Xie,Xiaohui Wang,Mengnan Li,Hai Zhang, Ruolin Mao,Na Zhang,Xiaohua Yang,
The Science of the total environment (2024): 170668-170668
Erik Melén,Rosa Faner,James P Allinson,Dinh Bui, Andrew Bush, Adnan Custovic, Judith Garcia-Aymerich,Stefano Guerra,Robab Breyer-Kohansal,Jenny Hallberg,Lies Lahousse,Fernando D Martinez,
The Lancetno. 10435 (2024): 1494-1503
Experimental and Molecular Pathology (2024): 104897-104897
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