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One line of research in the laboratory is to study how transcription factors impact pancreatic beta cell differentiation in vitro. For this, her talented post-doctoral fellow, Dr. Fiona Docherty established a 3-dimensional (3D) stem cell to pancreatic beta cell differentiation protocol (see Figure). This Diabetes UK funded project aims to identify druggable novel regulators of pancreatic beta cell differentiation with the aim of generating better functioning stem cell generated beta cells.
Another line of research in the Akerman lab focuses on studying the link between DNA replication and its potential regulatory effects on transcription and 3D genome structure during differentiation (of pancreatic beta cells). This project aims to clarify the cross-talk of two fundamental processes of a mammalian cell during development.
Another line of research in the Akerman lab focuses on studying the link between DNA replication and its potential regulatory effects on transcription and 3D genome structure during differentiation (of pancreatic beta cells). This project aims to clarify the cross-talk of two fundamental processes of a mammalian cell during development.
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论文共 43 篇作者统计合作学者相似作者
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DIABETIC MEDICINE (2023)
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Ruba Almaghrabi, Yara Alyayhawi,Peter Keane,Carl Ward,Rachel Bayley,Claudia Sargas, Pablo Menendez,George J. Murphy,Turki Sobahy,Mohammed A. Baghdadi,Arwa F Flemban,Saeed Kabrah,
biorxiv(2023)
crossref(2023)
Microbial genomicsno. 1 (2023)
Federica Cuozzo,Katrina Viloria,Ali H. Shilleh,Daniela Nasteska, Charlotte Frazer-Morris,Zicong Jiao, Adam Boufersaoui, Bryan Marzullo,Hannah R. Smith,Caroline Bonner,Julie Kerr-Conte, Francois Pattou,
biorxiv(2023)
Federica Cuozzo,Daniela Nasteska,Zicong Jiao,Hannah Smith,Caroline Bonner,Julie Kerr‐Conte, François Pattou,Rita Nano, Lorenzo Piemonti,Jennie Roberts,Gareth G. Lavery,İldem Akerman,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Endocrine Abstracts (2022)
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