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个人简介
My scientific career has been mainly focused on basic oncology research. During my PhD stage (1992-1997), at Dr. Fernandez-Piqueras’ laboratory at the Autónoma University of Madrid, I participated in the identification of new genes associated with psychiatric disorders as well as in the search of new tumor suppressor genes involved in human and mouse tumors. During my postdoctoral training (1998-2003), at Dr. Pellicer’s laboratory in the New York University School of Medicine, I worked actively in the discovery of ras signaling from endomembranes and the description of specific roles of N-ras in T-cell function. I also expanded my work on the study of the tumor suppressor gene p15 and its splicing variant p10. Since 2004, working in Dr. Malumbres’ laboratory at the CNIO, I have been the principal investigator of different projects on the Aurora kinase’ field. I have led a team that has been funded by private and public entities and has produced two PhD theses and a total of ten scientific publications. Using mouse models for Aurora kinases A and B and Tpx2, we have investigated the role of these mitotic regulators in embryo development and normal physiology of adult mammals as well as their potential as targets for anti-tumoral therapies. During this period, I have also studied the regulation of Aurora kinases by sumoylation and assisted in the search for new microRNAs involved in cancer or cell cycle regulation.
Since 2016, I have started my own research group (Gene Therpy) at the Carlos III Health Institute (ISCIII) to work on the study of rare diseases and orphan tumors. Our main goal is to better understand the mechanisms underlying these pathologies and find new therapeutical approaches to fight against them. Currently, we are foccused on the study of LMNA associated congenital muscular distrophies, granulosa cell tumors and the connection between chromosome instability and cancer.
研究兴趣
论文共 71 篇作者统计合作学者相似作者
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Sandra Amarilla-Quintana, Paloma Navarro, Alejandra Ramos, Ana Montero-Calle, Pablo Cabezas-Sainz, Maria J Barrero, Diego Megias, Borja Vilaplana-Marti,Carolina Epifano, Deborah Gomez-Dominguez, Ivan Hernandez, Sara Monzon,
biorxiv(2024)
SSRN Electronic Journalno. 7 (2023): 2090-2098
Ignacio Pérez de Castro, Cristina Aguirre-Portolés, Gonzalo Fernández-Miranda,Marta Cañamero, Dale O. Cowley,Terry Van Dyke,Marcos Malumbres
crossref(2023)
HUMAN GENE THERAPYno. 23-24 (2022): A24-A24
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Alberto Martín,Borja Vilaplana-Marti,Rocío IR Macías,Ángel Martínez-Ramírez,Ana Cerezo,Pablo Cabezas-Sainz, Maria Garranzo Asensio,Carolina Epifano, Sandra Amarilla,Déborah Gómez-Domínguez,Iván Hernández,Eduardo Caleiras,
biorxiv(2021)
D. Gomez-Dominguez, S. Amarilla,C. Epifano,A. Martin, B. Vilaplana-Marti,I. Hernandez, M. Pallares,I. Perez de Castro
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