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个人简介
My research is focused on several important ion channels of the nervous system including nicotinic acetylcholine receptors (nAChR), ionotropic glutamate receptors (IGR) and voltage-gated sodium channels and how their functioning is modulated by a variety of naturally occurring animal and plant toxins, drugs and pesticides. These compounds are excellent tools to study the structure and function of ion channels but also represent leads for the development of new drugs and pesticides and help us to understand problems such as pesticide resistance. Specific current interests are polyamine-containing toxins from solitary wasps, alkaloids from ladybirds, toxins from centipedes and pyrethroid insecticides. I am also interested in the development of multi-target directed ligands for Alzheimer's disease, in my case assessing their ability to inhibit NMDA receptor mediated calcium current.
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Life (Basel, Switzerland)no. 4 (2023): 1019-1019
Filippo Basagni,Jose A Ortega, Sine M Bertozzi,Andrea Armirotti,Maria Summa,Rosalia Bertorelli,Manuela Bartolini,Ian R Mellor,Martina Bedeschi,Giovanni Bottegoni, Vittorio Lembo,Anna Minarini,
European journal of medicinal chemistry (2023): 115803-115803
Journal of Herbmed Pharmacologyno. 2 (2022): 166-181
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D-Core
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