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We study embryonic stem cells (ESCs). These cells are pluripotent, meaning they can change into all the cell types of our bodies (differentiation). ESCs can also divide to produce cells identical to themselves, a process termed self-renewal. The simultaneous possession of these properties is what makes ESCs useful.
Pluripotent cell identity is controlled by the action of transcription factors (TFs) that together form cell-specific gene regulatory networks. In ESCs the gene regulatory network is centred on the TFs OCT4, SOX2 and NANOG. We identified NANOG in a genetic screen, searching for molecules that could allow ESCs to self-renew in the absence of the otherwise obligatory cytokine, LIF. Because of this phenotype, we named it Nanog, after Tir nan Og, the mythological Celtic land of the ever-young, where visitors remain unaged. We use Nanog as a tool to investigate how pluripotent cells are regulated.
Pluripotent cell identity is controlled by the action of transcription factors (TFs) that together form cell-specific gene regulatory networks. In ESCs the gene regulatory network is centred on the TFs OCT4, SOX2 and NANOG. We identified NANOG in a genetic screen, searching for molecules that could allow ESCs to self-renew in the absence of the otherwise obligatory cytokine, LIF. Because of this phenotype, we named it Nanog, after Tir nan Og, the mythological Celtic land of the ever-young, where visitors remain unaged. We use Nanog as a tool to investigate how pluripotent cells are regulated.
Research Interests
Papers共 138 篇Author StatisticsCo-AuthorSimilar Experts
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Boyan Huang, Xing Peng,Xuzhao Zhai, Jie Hu, Junyu Chen, Suming Yang, Qingpei Huang,Enze Deng,Huanhuan Li,Tahsin Stefan Barakat,Jiekai Chen,Duanqing Pei,
Developmental Cell (2024)
Boyan Huang, Jie Hu, Xing Peng,Qingpei Huang, Laru Peng,Enze Deng,Tahsin Stefan Barakat,Jiekai Chen,Duanqing Pei,Xiaoying Fan,Ian Chambers, Man Zhang
Social Science Research Network (2022)
Stem cell reportsno. 1 (2021): 35-42
Ian Chambers, Praveen Kumar,Jens Lichtenberg, Pengcheng Wang, Jianshi Yu,John Phillips,Maureen Kane,David Bodine,Iqbal Hamza
Proceedings of the National Academy of Sciencesno. 6 (2021)
semanticscholar(2021)
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