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个人简介
The overarching theme of the research in this group is the investigation of the molecular mechanisms underlying chronic inflammation in severe asthma and COPD and how these processes are affected by oxidative stress and by corticosteroids. These studies are performed in both cultured and primary airway structural cells (epithelial cells and smooth muscle cells), T-cells and monocytes/macrophages, in human lung tissues and in animal models of disease. As a group we use molecular, pharmacological and histological techniques including reporter gene assays, overexpression, Western blotting, RT-qPCR, confocal imaging, chromatin immunoprecipitation, 3C analysis, transcriptomic analysis, SILAC/iTRAQ and siRNA. There is a major focus on translational research with the application of state-of-the-art molecular techniques to primary cells from patients with airways disease. We work closely with colleagues within other groups in Airways Disease such as Professor Chung (Severe Asthma), Professors Barnes and Donnelly (COPD) and Dr Usmani (Small Airways) to enable better translational research. We also collaborate with other researchers within NHLI to examine inflammatory responses to infections (Professor Johnston), in pulmonary hypertension (Dr Wort), in fibrosis (Dr Renzoni) and following heart surgery (Professor Angelini).
研究兴趣
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