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Bio
Dr. Ismael Valladolid Acebes obtained his PhD at CEU-San Pablo University and he is currently assistant professor at Karolinska Institutet. Among his investigations aimed at linking metabolic diseases to brain derangements, the most remarkable scientific contributions are related to the mechanisms by which impaired leptin signalling within the hippocampus, upon consumption of high-fat diet during the adolescence, lead to an imbalance between the stimulus-dependent release of excitatory and inhibitory neurotransmitters in the synaptic cleft of obese mice. His investigations resulted in the publication of seven research articles, of which the applicant signed three of them as a first author. The relevance of these findings in generating new hypotheses gave to the candidate the opportunity to continue developing his research career as a postdoc at Karolinska Institutet. During the postdoctoral period of the candidate, he has been able to demonstrate that minor differences in the molecular machinery mediating regulated membrane fusion has major impact on metabolic health. Leading his own projects and cooperating with other research groups in Sweden and abroad, the candidate was able to uncover unanswered questions on the role of synaptosomal-associated protein 25 splice isoform b (SNAP-25b) as a key regulatory exocytotic protein linking metabolic syndrome to degeneration of liver sympathetic nerves and their deleterious consequences for brain structure and function. These projects were, at least in part, possible due to the funding acquired by the candidate from private foundations, with a contribution of about 20,000 € as principal investigator. The research success during the candidate´s postdoctoral training is reflected by the publication of six peer-reviewed articles, two of which he signed as a first author. Furthermore, the candidate´s scientific technical skills together with the knowledge acquired during his postdoc allowed him to train and supervise five international undergraduate students, one postdoc and two PhD candidates up to the date of their defence. The scientific imprint that the candidate left on his students is evidenced by the fact that all of them have successfully continued their scientific careers, both within the academy and in the pharmaceutical industry. The scientific responsibilities exercised up to that moment, together with the leadership shown during his postdoc coordinating international projects, earned him the promotion to assistant professor. This upgrade allowed the candidate to consolidate a research team consisting of a clinician, a senior lab manager and a PhD student under his supervision. The driving force of this team is aimed at finding new therapeutic strategies to protect against metabolic diseases linked to brain disorders by targeting apolipoprotein CIII (apoCIII), an important pro-inflammatory liver factor whose levels are increased in obesity and diabetes mellitus. Several goals were achieved by the candidate in this framework; first, contributing a mechanism by which apoCIII reduction prevents and reverses obesity, type-2 diabetes and NAFLD; second, generating new research lines aimed to develop innovative and more potent therapeutic strategies to target apoCIII with small interfering RNAs (siRNAs) in cooperation with leading pharmaceutical companies; third, publishing the outcomes of his group and his collaborations in eight peer-reviewed articles; fourth, providing economical support for the development of his projects with contributions of around 30,000 €; and fifth, disseminating the candidate´s cutting-edge advances by participating in a number of conferences, by giving lectures and by providing visibility to his research in the media for the general audience.
Research Interests
Papers共 34 篇Author StatisticsCo-AuthorSimilar Experts
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Electron Microscopy [Working Title] (2022)
Antioxidantsno. 1070 (2021): 1070
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Author Statistics
#Papers: 38
#Citation: 781
H-Index: 15
G-Index: 27
Sociability: 5
Diversity: 0
Activity: 0
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