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个人简介
Ismael Samudio obtained his Ph.D. in genetics from Texas A&M University and received postdoctoral training in pharmacology and toxicology at the Institute of Biotechnology in Houston. In 2004 he joined the Section of Molecular Hematology at MD Anderson Cancer Center (MDACC) where he led and supported various clinical and pre-clinical studies on the anti-leukemic and anti-tumor effects of various targeted agents, including the MDM-2 inhibitor Nutlin 3a (Idasanutlin) and the orally active bcl-2 inhibitors ABT-737, ABT-199, and the recently approved Navitoclax. While at MD Anderson, Ismael also conducted seminal work demonstrating that the Warburg effect in leukemias was a consequence of uncoupled mitochondrial respiration resulting in the reliance of leukemic stem cells on fatty acid oxidation for survival and chemoresistance. In addition, in collaboration with Dr. Michael Andreeff and Dr. Frank Marini, he demonstrated the therapeutic efficacy of gene-modified mesenchymal stromal cells in animal models of pancreatic and ovarian cancer.
In 2015, Ismael was recruited to the Centre for Drug Research and Development (CDRD) to lead a nascent immunotherapy initiative, eventually becoming director of the Biologics Division where he led the discovery & development of several novel anti-tumor biotherapeutics of various formats, including CAR-T, antibody drug-conjugates (ADC), and functional antibodies. In 2019 he became senior director of research for Virogin biotech, where he was responsible for overseeing the development of the oncolytic virotherapy pipeline and the analysis of exploratory endpoints from the company’s first clinical trial of a novel attenuated herpes virus simplex expressing IL12, IL15, and a PD-L1 blocking peptide. Most recently, Ismael joined Notch Therapeutics as the senior director of Cancer Biology & Translational Sciences where he oversees the discovery pipeline of cellular therapeutics for various human diseases. Ismael has published over 70 peer reviewed articles and various book chapters on the use of small molecules, cellular therapeutics, and immunotherapy strategies for the treatment of cancer, and is coinventor on multiple therapeutic patents.
研究兴趣
论文共 166 篇作者统计合作学者相似作者
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MOLECULAR THERAPY-ONCOLYTICS (2023): 334-348
crossref(2023)
VIRUSES-BASELno. 11 (2022): 2327
Cancer Researchno. 13_Supplement (2021): 1913-1913
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