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One of the main aims of the research in my lab is to elucidate the molecular basis of neurodegeneration. Since no unbiased genetic screens in model organisms were performed to sample genes that cause neurodegenerative phenotypes, we embarked on such a screen in fly photoreceptors and isolated 700 mutations corresponding to 165 complementation groups. This screen has provided a very rich resource of novel mutants for the fly community, and has permitted us to dissect mechanisms for a variety of diseases, including Charcot-Marie-Tooth disease, Leigh syndrome and Friedreich’s ataxia. This screen has also led to the identification of mutations in 32 genes that encode proteins that are targeted to mitochondria. By exploring the molecular mechanisms of these rare diseases we were able to determine that biochemical pathways are affected that also play a role in Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Alzheimer’s disease. These pathways are now being studied intensely in the lab.
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论文共 478 篇作者统计合作学者相似作者
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Jenny Zhe Liao,Hyung-lok Chung, Claire Shih,Kenneth Kin Lam Wong,Debdeep Dutta,Zelha Nil, Catherine Grace Burns,Oguz Kanca,Ye-Jin Park,Zhongyuan Zuo,Paul C. Marcogliese, Katherine Sew,
Nature Communicationsno. 1 (2024)
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EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 6-7
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Nature Neuroscienceno. 4 (2024): 1-3
Ye-Jin Park,Tzu-Chiao Lu,Tyler Jackson,Lindsey D Goodman, Lindsey Ran,Jiaye Chen,Chung-Yi Liang, Erin Harrison, Christina Ko,Ao-Lin Hsu,Shinya Yamamoto,Yanyan Qi,
bioRxiv : the preprint server for biology (2024)
Jenny Zhe Liao,Hyung-Lok Chung, Claire Shih,Kenneth Kin Lam Wong,Debdeep Dutta,Zelha Nil, Catherine Grace Burns,Oguz Kanca,Ye-Jin Park,Zhongyuan Zuo,Paul C Marcogliese, Katherine Sew,
Nature communicationsno. 1 (2024): 3326-3326
Walker Peterson, Joshua Arenson, Soichiro Hata, Laura Kacenauskaite, Tsubasa Kobayashi, Takuya Otsuka, Hanqing Wang,Yayoi Wada,Kotaro Hiramatsu, Zhikai He,Jean-Emmanuel Clement, Chenqi Zhang,
crossref(2024)
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Genetics in Medicine Open (2024): 101494
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