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Hugh Markus
Professor
Department of Clinical Neurosciences
University of Cambridge;BHF Cambridge Centre of Excellence, University of Cambridge;Cardiovascular Interdisciplinary Research Centre, University of Cambridge;Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge
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Bio
I use molecular genetic and neuroimaging (MRI and Transcranial Doppler) techniques to investigate the pathogenesis of, and develop treatments for, cerebrovascular disease.
A particular interest is in cerebral small vessel disease, a major cause of stroke and the major cause of vascular cognitive impairment; here we are studying genetic determinants (for both monogenic and polygenic disease), the mechanisms of cognitive decline using advanced multimodal MRI, and evaluating new therapeutic approaches. Our imaging projects involve the application of MRI and PET to look at blood brain barrier leakage and glial activation (neuroinflammation in man, and the use of diffusion tensor MRI to determine how vascular damage leads to white matter damage and cognitive impairment.
I am involved in a number of international studies of stroke genetics including the WTCCC2 ischaemic stroke study which we led, METASTROKE which we established and MEGASTROKE all as part of the the International Stroke Genetics Consortium. I run a National clinical referral service for patients with the monogenic from of stroke CADASIL.
A particular interest is in cerebral small vessel disease, a major cause of stroke and the major cause of vascular cognitive impairment; here we are studying genetic determinants (for both monogenic and polygenic disease), the mechanisms of cognitive decline using advanced multimodal MRI, and evaluating new therapeutic approaches. Our imaging projects involve the application of MRI and PET to look at blood brain barrier leakage and glial activation (neuroinflammation in man, and the use of diffusion tensor MRI to determine how vascular damage leads to white matter damage and cognitive impairment.
I am involved in a number of international studies of stroke genetics including the WTCCC2 ischaemic stroke study which we led, METASTROKE which we established and MEGASTROKE all as part of the the International Stroke Genetics Consortium. I run a National clinical referral service for patients with the monogenic from of stroke CADASIL.
Research Interests
Papers共 838 篇Author StatisticsCo-AuthorSimilar Experts
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Fluids and Barriers of the CNSno. 1 (2024): 1-13
Audrey Low, Sanne van Winden, Lupei Cai,Roy P. C. Kessels,Marnix C. Maas,Robin G. Morris,Meritxell Nus,Daniel J. Tozer,Anil Tuladhar,Anja van der Kolk, Rowan Wolters,Ziad Mallat,
BMJ OPENno. 2 (2024): e084303-e084303
Shadi Yaghi,Liqi Shu, Lauren Fletcher,Fayez H Fayad,Asghar Shah,Ana Herning, Noail Isho, Perla Mansour,Kareem Joudi,Bashar Zaidat,Noor A Mahmoud, Feras Abdul Khalek,
Strokeno. 7 (2024): 1776-1786
INTERNATIONAL JOURNAL OF STROKEno. 6 (2024): 17474930241245613-17474930241245613
INTERNATIONAL JOURNAL OF STROKEno. 4 (2024): 376-378
Strokeno. 4 (2024): 934-942
Stephen Brennan,Peter J Kelly,Sarah Gorey,Pádraig Synnott,Dipender Gill,Martin Dichgans,Marios K Georgakis,Marie-Joe Dib,Eloi Gagnon, Niall Gerard Mahon,Gavin Blake,Christina Jern,
medrxiv(2024)
Strokeno. 4 (2024): 1032-1040
Claudia Pallucca,Danuta M Lisiecka-Ford, Lisa Wood, Azim Abul,Amy A Jolly,Daniel J Tozer,Steven Bell,Anne Forster,Robin G Morris,Hugh S Markus
Neurologyno. 3 (2024): e208052-e208052
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Author Statistics
#Papers: 840
#Citation: 66598
H-Index: 129
G-Index: 236
Sociability: 9
Diversity: 3
Activity: 136
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