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My lab studies the ways in which ion channels control membrane potential and intracellular calcium signalling in cancer cells. Cancers such as pancreatic neuroendocrine tumours, small-cell lung cancer and some breast and prostate cancers show neural characteristics, including excitability and vesicular release of peptides and neurotransmitters. We are interested in how such signalling participates in the invasiveness and progression of these cancers. As well as these neuroendocrine-differentiated cancers, we are interested in how brain-metastatic cancer cells interact with neurons, and how neurotransmitter signalling at synapses promotes survival, invasion and growth of brain metastases, for example of breast cancer. We use a combination of patch-clamp and optical recording techniques, cell culture and computational modelling.
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Cambridge University Press eBookspp.7-11, (2023)
Hugo Zeberg,Michael Dannemann,Kristoffer Sahlholm, Kristin Tsuo,Tomislav Maricic, Victor Wiebe,Wulf Hevers,Hugh P C Robinson,Janet Kelso,Svante Pääbo
Current biology : CBno. 17 (2020): 3465-3469.e4
semanticscholar(2018)
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