Dr. Sampson's research interests have focused on food allergic disorders, and now include work on the pathogenesis of food-induced anaphylaxis, characterization of allergenic food proteins and their processing by the immune system, genetics of food allergy, development of novel diagnostic tests, and mechanisms of immunotherapeutic strategies for treating food allergies including basic studies and clinical trials in oral, sublingual and epicutaneous immunotherapy and the potential use of biologics, such as anti-IgE and anti-cytokine monoclonal antibodies. His research is funded by a number of grants from the National Institutes of Health, including the recently funded Exposure to Vaginal Microbiome in C-section Infants at High-risk for Allergies – A Pilot Study. Dr. Sampson supervises one clinic/week in pediatric allergy and is involved in teaching fellows and residents. He is an Associate Editor of Pediatric Allergy & Immunology, past-president of the American Academy of Allergy, Asthma & Immunology, and a member of the National Academy of Medicine.