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Metabolomics, a newly emerging field of ‘omics’ research, is the study of the entire sets of small molecules (termed metabolome, molecular weight < 1500 Da), in a given biological system, such as a cell, organ, whole organism or biofluid. The metabolome is a close counterpart to the genome, the transcriptome and the proteome. Together these four ‘omics’ constitute the building blocks of systems biology. Unlike genes and proteins whose functions are subject to epigenetic regulation and post-translational modifications, respectively, metabolites serve as a direct functional readout of a current cellular state and therefore easier to correlate with phenotype. This fact has made metabolomics particularly useful in the study of environment-gene interactions, the identification of disease biomarkers, and the discovery of drugs.
Metabolomics, a newly emerging field of ‘omics’ research, is the study of the entire sets of small molecules (termed metabolome, molecular weight < 1500 Da), in a given biological system, such as a cell, organ, whole organism or biofluid. The metabolome is a close counterpart to the genome, the transcriptome and the proteome. Together these four ‘omics’ constitute the building blocks of systems biology. Unlike genes and proteins whose functions are subject to epigenetic regulation and post-translational modifications, respectively, metabolites serve as a direct functional readout of a current cellular state and therefore easier to correlate with phenotype. This fact has made metabolomics particularly useful in the study of environment-gene interactions, the identification of disease biomarkers, and the discovery of drugs.
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论文共 121 篇作者统计合作学者相似作者
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Tingting Zhao, Kristin Carroll, Caley B. Crauen,Nicholas J. P. Wawryk,Shipei Xing,Jian Guo,Xing-Fang Li,Tao Huan
Journal of Environmental Sciences (2024): 583-593
Tingting Zhao, Kristin Carroll, Caley B. Crauen, Nicholas J. P. Wawryk,Shipei Xing,Jian Guo, Xing-Fang Li,Tao Huan
JOURNAL OF ENVIRONMENTAL SCIENCES (2024): 583-593
iScienceno. 4 (2024): 109382-109382
Charlotte F Chao,Yanina-Yasmin Pesch,Huaxu Yu, Chenjingyi Wang,Maria J Aristizabal,Tao Huan, Guy Tanentzapf,Elizabeth Rideout
eLife (2024)
Tingting Zhao,Nicholas J. P. Wawryk,Shipei Xing,Brian Low, Gigi Li,Huaxu Yu, Yukai Wang,Qiming Shen,Xing-Fang Li,Tao Huan
ANALYTICAL CHEMISTRYno. 6 (2024): 2590-2598
Zixuan Zhang,Huaxu Yu, Ethan Wong-Ma,Pouneh Dokouhaki,Ahmed Mostafa,Jay S. Shavadia,Fang Wu,Tao Huan
ANALYTICAL CHEMISTRYno. 9 (2024): 3727-3732
Charlotte Chao, Yanina-Yasmin Pesch, Huaxu Yu, Chenjingyi Wang, Maria J Aristizabal,Tao Huan, Guy Tanentzapf,Elizabeth Rideout
crossref(2024)
TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024): 117541
NATURE METHODSno. 6 (2023): 799-800
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