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个人简介
Our research efforts have been focused on the characterization of molecular mechanisms and the development of novel therapies for cancer by a combination of computational and molecular biology approaches. We reported that long non-coding RNAs exhibit genomic alterations with high frequency in cancer (Cancer Cell 2014, and Cancer Cell 2015). We developed novel strategies to target DNA repair pathways in combination with inhibition of certain long non-coding RNA or epigenetic regulators to treat breast and ovarian cancer (Nature Structural and Molecular Biology 2016, Science Translational Medicine 2017, and Cell Reports 2020). Recently, by integrating large-scale and multi-dimensional genomic profiles, we developed a Functional Cancer Genome data portal (FCG data portal: http://52.25.87.215/home/) to functionally annotate TCGA genomic profiles. Examples include annotations on the relationship between genetic ancestry and genomic alteration (Cancer Cell 2018) and genomic alterations in epigenetic regulatory genes (Nature Communications 2019, and Cell Reports 2022). Our early and still ongoing research is directed towards investigating the antitumor immune response and developing immunotherapy strategies for ovarian cancer. Our studies provided strong clinical evidence to support the concept of immune surveillance in ovarian cancer (Nature Cancer 2021).
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bioRxiv : the preprint server for biology (2024)
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