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RESEARCH SUMMARY
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
Research Interests
Papers共 666 篇Author StatisticsCo-AuthorSimilar Experts
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CYTOKINE (2024): 156544-156544
Maria Estefania Viano,Natalia Soledad Baez,Constanza Savid-Frontera,Ruth Eliana Baigorri,Brenda Dinatale,Maria Florencia Pacini,Camila Bulfoni Balbi,Florencia Belén Gonzalez,Laura Fozzatti, Nicolas Leonel Lidón,Howard A Young,Deborah L Hodge,
Microbes and infectionno. 5-6 (2024): 105337-105337
Enitome E Bafor,Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker,Adrienne E Kimmel, Olivier Duverger,John M Fenimore, Meredith Ramba, Thea Spindel,Megan M Hess,Michael Sanford,Vanja Lazarevic,
Frontiers in immunology (2024): 1368572-1368572
Microbes and Infection (2024)
Microbes and Infectionpp.105337, (2024)
crossref(2023)
Cancer Researchno. 7_Supplement (2023): 5138-5138
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Cytokine (2023): 156159-156159
Cancer Researchno. 11_Supplement (2023)
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