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My research program is concerned with examining the acute and chronic changes that occur in skeletal muscle in response to perturbations in energy homeostasis. Particular attention is given both to the metabolic pathways involved in the generation of energy and to the excitation and contraction processes that utilize energy. Presently, we are employing a number of models designed to either increase ATP utilization (electrical stimulation, voluntary activity) or to reduce ATP availability (hypoxia, ischemia, hypervolemia). We also are involved in studying skeletal muscle in selected disease states such as chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD), where aerobic metabolisms is compromised as a result of reduced oxygen availability. Although the major focus of our efforts is directed at describing the remodeling that occurs in the cell at all levels of organization (histochemical, enzymatic, ultrastructural, molecular) and the factors governing altered protein expression, we are also interested in the consequences of the adaptations, as determined during exercise, on mechanical function and fatiguability, substrate and ionic flux. Ultimately, we hope to be able to determine the strategies employed, both in health and disease, to defend against challenges to muscle energy balance.
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Chemistry and Physics of Lipids (2015): 56-61
John P Mattson, Steve Lloyd,Timothy I Musch,Torben Clausen, J R Fowles,Howard J Green,J Ouyang,Dale J Barr,David Lounsbury,James W E Rush,Jianhua Li,Zhaohui Gao,
mag(2015)
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T A Duhamel,Howard J Green, R D Stewart, K P Foley,Ian C Smith,J Ouyang,Melissa M Thomas,Chris Vigna,Andrew C Betik,A Russell Tupling,Russell T Hepple
mag(2015)
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mag(2015)
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