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Bio
RESEARCH SUMMARY
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
Research Interests
Papers共 644 篇Author StatisticsCo-AuthorSimilar Experts
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CYTOKINE (2024): 156544-156544
Enitome E Bafor,Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker,Adrienne E Kimmel,Olivier Duverger,John M Fenimore, Meredith Ramba, Thea Spindel,Megan M Hess,Michael Sanford,Vanja Lazarevic,
Frontiers in immunology (2024): 1368572-1368572
Microbes and Infectionno. 5-6 (2024): 105337-105337
Weici Zhang, Taha Al Tekreeti,Patrick S C Leung,Koichi Tsuneyama, Harleen Dhillon, Manuel Rojas, Luke S Heuer, William M Ridgway,Aftab A Ansari,Howard A Young,Charles R Mackay,M Eric Gershwin
Liver international : official journal of the International Association for the Study of the Liver (2024)
Cancer Researchno. 7_Supplement (2023): 5138-5138
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Cytokine (2023): 156159-156159
Frontiers in Immunology (2023): 1021824-1021824
GASTROENTEROLOGYno. 6 (2023): S1259-S1259
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Author Statistics
#Papers: 643
#Citation: 42276
H-Index: 108
G-Index: 194
Sociability: 8
Diversity: 3
Activity: 71
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