基本信息
浏览量:186
职业迁徙
个人简介
Research Synopsis
Cancer arises from breakdown in the normal cellular regulatory system. This malfunction can be a consequence of genetic mutation as well as epigenetic changes. Key epigenetic alterations, including histone modification and DNA methylation, often result in global as well as localized chromatin packaging that influences the transcription of genes important to cancer. Drugs that modify the epigenetic state promise to be effective new cancer therapies. However, the mechanism(s) underlying the epigenetic regulation of cancer cells, as well as the way in which drugs manipulate the epigenetic state and transcription, remain largely unknown. Moreover, as epigenetic regulation is critical for maintaining normal cellular function, the characterization of cancer-specific epigenetic reprogramming is an essential step for increasing specificity of epigenetic therapy. Noncoding RNAs, particularly long non-coding RNA (lncRNA) and circular RNA (circRNA), have recently become a new area of focus in cancer biology, with evidence suggesting that they are essential to epigenetic reprogramming during cancer development and progression.
Cancer arises from breakdown in the normal cellular regulatory system. This malfunction can be a consequence of genetic mutation as well as epigenetic changes. Key epigenetic alterations, including histone modification and DNA methylation, often result in global as well as localized chromatin packaging that influences the transcription of genes important to cancer. Drugs that modify the epigenetic state promise to be effective new cancer therapies. However, the mechanism(s) underlying the epigenetic regulation of cancer cells, as well as the way in which drugs manipulate the epigenetic state and transcription, remain largely unknown. Moreover, as epigenetic regulation is critical for maintaining normal cellular function, the characterization of cancer-specific epigenetic reprogramming is an essential step for increasing specificity of epigenetic therapy. Noncoding RNAs, particularly long non-coding RNA (lncRNA) and circular RNA (circRNA), have recently become a new area of focus in cancer biology, with evidence suggesting that they are essential to epigenetic reprogramming during cancer development and progression.
研究兴趣
论文共 144 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Manisha Yadav,Rachel J Harding,Tiantian Li,Xin Xu,Terence Gall-Duncan,Mahreen Khan,Costanza Ferrari Bardile, Glen L Sequiera,Shili Duan,Renu Chandrasekaran, Anni Pan,Jiachuan Bu,
biorxiv(2024)
Xavier Farre, Miguel Angel Pardo, Ana Esteve,Francesca Mateo, Roderic Espin, Joanna Palade,Bessie Meechoovet, Marc Alorda,Natalia Blay,Alexandra Baiges, Arzoo Shabbir, Francesc Comellas,
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 566-567
引用0浏览0引用
0
0
Gastroenterologyno. 2 (2023): 445-462
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2023): 1-15
Julia Nguyen,Anthony Mammoliti, Sisira Kadambat Nair,Emily So, Farnoosh Abbas-Aghababazadeh, Christoper Eeles,Ian Smith, Petr Smirnov,Housheng Hansen He, Ming-Sound Tsao,Benjamin Haibe-Kains
biorxiv(2023)
crossref(2023)
Molecular Cellno. 15 (2023): 2692-2708.e7
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn