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urrent Research
DNA replication and transcription occur concurrently and on the same template in all organisms. This leads to inevitable encounters between the two processes that inhibit replication progression, disrupt the integrity of the replication machinery, and increase mutagenesis. Therefore the avoidance and resolution of replication-transcription conflicts is essential for faithful duplication of genomes and survival of cells. Furthermore, due to the mutagenic nature of these encounters, conflicts can impact evolution and promote disease. Our lab studies the consequences of these collisions on physiology and evolution. We take advantage of cutting edge technology such as in vivo single molecule microscopy, deep sequencing, bioinformatics analyses, as well as basic genetics and biochemical approaches. Due its simplicity with respect to chromosome structure and DNA replication, we generally employ the bacterial model organism Bacillus subtilis for these studies. However, we are now beginning to determine if and how conflicts impact the development of antibiotic resistance in pathogenic bacteria, and generation of cancer in eukaryotic organisms.
DNA replication and transcription occur concurrently and on the same template in all organisms. This leads to inevitable encounters between the two processes that inhibit replication progression, disrupt the integrity of the replication machinery, and increase mutagenesis. Therefore the avoidance and resolution of replication-transcription conflicts is essential for faithful duplication of genomes and survival of cells. Furthermore, due to the mutagenic nature of these encounters, conflicts can impact evolution and promote disease. Our lab studies the consequences of these collisions on physiology and evolution. We take advantage of cutting edge technology such as in vivo single molecule microscopy, deep sequencing, bioinformatics analyses, as well as basic genetics and biochemical approaches. Due its simplicity with respect to chromosome structure and DNA replication, we generally employ the bacterial model organism Bacillus subtilis for these studies. However, we are now beginning to determine if and how conflicts impact the development of antibiotic resistance in pathogenic bacteria, and generation of cancer in eukaryotic organisms.
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Kaitlyn R Browning,Houra Merrikh
Kaitlyn R. Browning,Houra Merrikh
MBIOno. 1 (2024): e0273723-e0273723
arxiv(2023)
arXiv (Cornell University) (2022)
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