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His present focus of research is the elucidation of the structure and function of ligand-gated ion channels and G-protein coupled receptors.
These two classes of membrane proteins cover the majority of human membrane proteins, play a central role in proper functioning of cells, are involved in many severe diseases, and therefore are among the most important targets for presently used therapeutic compounds. High-resolution structures of the proteins as well as their functional interplay in the cellular biochemical network are required for a proper understanding of their function and will facilitate the development of novel medicines to treat diseases which are evoked by a malfunction of these membrane proteins.
The different structural states during the activation process of these receptors and their interactions with cellular signalling molecules will be investigated in their native cellular environment using cryo-electron and optical microscopies, combined with complementary biophysical techniques. Close collaboration with computational biology groups in the institute is of central for these projects.
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Nature communicationsno. 1 (2024): 110-110
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Haijian Li, Xiaolin Sun,Wenqiang Cui, Marc Xu,Junlin Dong,Babatunde Edukpe Ekundayo,Dongchun Ni, Zhili Rao, Liwei Guo,Henning Stahlberg,Shuguang Yuan,Horst Vogel
Nature biotechnologyno. 2 (2024): 229-242
Hang Zhang,Shiyu Wang,Zhenzhen Zhang,Mengzhuo Hou,Chunyu Du, Zhenye Zhao,Horst Vogel,Zhifang Li,Kaige Yan,Xiaokang Zhang,Jianping Lu,Yujie Liang,
Nature Communicationsno. 1 (2023): 1-13
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WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCEno. 2 (2022)
Pharmacological reviewsno. 1 (2021): 310-520
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